X Particles 259 Serial 33
The Falcon 2000LXS will offer an advanced filtration system option that improves air quality even further. HEPA/ULPA filters*, found in most hospital intensive care units and operating rooms, collect 99.97% of all air particles, including 0.06 to 0.2 µm particles** such as: COVID-19, MERS-CoV and SARS-CoV. System certification for deliveries in 2022 is currently pending.
X Particles 259 Serial 33
Vetrees et al (2008) reported on a retrospective review of outcomes of surgical repair of 83 patients with open abdomen that were treated at Walter Reed Army Medical Center. Surgical management included early definitive abdominal closure (EDAC) (serial abdominal closure with prosthetic Gore-Tex Dualmesh and final closure supplemented with polypropylene mesh or Alloderm in 56 patients, primary fascial closure in 15 patients, planned ventral hernia (PVH) in 9 patients, and vacuum-assisted closure with Alloderm in 3 patients). Complications included removal of infected prosthetic mesh in 4 EDAC closure patients; the investigators noted that mesh-related complications had decreased over time. The investigators reported that rates of infection, abdominal wall hematoma, deep venous thrombosis, and pulmonary embolism did not differ between groups. In the EDAC group, infections complicated final polypropylene mesh closure in 3 of 28 patients closed with prosthetic mesh; 1 of 14 patients closed with biologic mesh (Alloderm) noted increased laxity at the repair site. Of 56 patients treated with EDAC, 2 patients had recurrent ventral hernia. Of the 3 patients closed with Alloderm and vacuum assisted closure, 1 patient had recurrent ventral hernia. The investigators reported that no final Alloderm closures required removal after placement, but "long-term results have been disappointing ... The excessive cost of biologic material requires better results than those documented in previous studies." Limitations of this study include its lack of randomization, variation in the described closure methods, its retrospective nature, and limitations of some data points. The investigators concluded that "polypropylene mesh final EDAC closure risks infection and subsequent fistula formation, and long-term follow-up are needed. Use of biologic mesh as either final EDAC closure or with vacuum-assisted closure also requires long-term follow-up to justify its increased cost and increased risk of abdominal wall laxity."
Amniotext (Regenative Labs) is a minimally manipulated, amniotic membrane derived, human tissue allograft suspension product. The product serves to provide a barrier/support function and to aid in healing of defect. It is intended to provide the extracellular matrix needed for the infiltration, attachment and proliferation of cells required for the repair of damaged tissue. Amniotic membrane human tissue-based products have shown to reduce scarring, fibrosis and adhesions in surgical and wound sites. It is administered through a syringe to the defect and the amount is determined by the clinician based on the size of the defect. Each human tissue-based product distributed by Regenative Labs is identified by its own unique serial number. The product is packaged in a transport protective pouch. The product is contained in a cryogenic primary tissue container, which contains a product label that includes the product details such as unique product number, storage requirements and volumes. Contents are aseptically processed and are not considered sterile.
Amniotext patches (Regenative Labs) are minimally manipulated, amniotic membrane-derived, human tissue allografts. The product serves as wound covering. It is typically used for chronic non-healing wounds such as diabetic foot ulcers and venous leg ulcers. It provides the extracellular matrix needed for the infiltration, attachment and proliferation of cells required for repair of damaged tissue. The graft is applied directly to the wound bed and is available in various sizes, the size used matches the wound defect. Each human tissue-based product distributed by Regenative Labs is identified by its own unique serial number. The product is packaged in a transport protective pouch. The product is contained in a dual package tissue container system, in which the outermost ploy-foil pouch contains a product label that includes the product details such as unique product number, storage requirements and size. Contents are aseptically processed and sterilized, and are considered sterile.
Stern et al (1990) stated that Integra artificial skin is an effective means of treatment for full-thickness burns. In this histological study, serial biopsy specimens were obtained from 131 patients during a period of 7 days to 2 years after application; 6 sequential phases of repair were discerned. Additionally, there were occasional unusual histological features, eosinophilic infiltration, and/or macrophage-derived giant cell formation in the wound area; however, such findings did not clinically correlate with a negative response to Integra. These investigators found that the use of Integra resulted in good repair, with rare exceptions. An intact dermis was achieved as well as definitive closure of a complete epidermal layer with a minimum of scarring.